This article details the five candidates who raised the most money and lost their election. In the 2022 election cycle, 20 of 20 general elections were contested. The losing candidates are shown along with the percentage of the vote they received compared to the winner. In cases where the race was pushed to a runoff, vote percentages for both advancing candidates are included.

General elections for 20 of 40 seats in the California State Senate will take place on November 8, 2022. State senatorial open primary elections were held on June 7, 2022. Democrats hold a 31-9 majority heading into the election.