This article details the five candidates in each party who raised the most money and lost their primary election. In the 2022 election cycle, 15 of 49 Republican primaries and seven of 37 Democratic primaries were contested. The losing candidates are shown along with the percentage of the vote they received compared to the primary winner. In cases where the race was pushed to a runoff, vote percentages for both advancing candidates are included.

The stakes were particularly high for the 2020 elections, and not just for the presidency. At the state-level, some of the most closely watched races were Democratic efforts to flip swing state legislatures blue and take control of the upcoming redistricting process.