This article details the five candidates who raised the most money and lost their election. In the 2022 election cycle, 22 of 26 general elections were contested. The losing candidates are shown along with the percentage of the vote they received compared to the winner. In cases where the race was pushed to a runoff, vote percentages for both advancing candidates are included.

General elections for 26 of 50 districts in the Pennsylvania State Senate took place on Nov. 8, 2022. Of the 26 districts up for election in 2022, 22 had a General election with more than one candidate.