Republican primary elections for 22 of 49 seats in the Pennsylvania State Senate took place on May 17, 2022. Of the 22 seats up for election in 2022, nine had a primary election with more than one candidate.

This article details the five candidates in each party who raised the most money and lost their primary election. In the 2022 election cycle, nine of 22 Republican primaries and four of 22 Democratic primaries were contested. The losing candidates are shown along with the percentage of the vote they received compared to the primary winner. In cases where the race was pushed to a runoff, vote percentages for both advancing candidates are included.