This article details the five candidates who raised the most money and lost their election. In the 2022 election cycle, 59 of 100 general elections were contested. The losing candidates are shown along with the percentage of the vote they received compared to the winner. In cases where the race was pushed to a runoff, vote percentages for both advancing candidates are included.

In Indiana, state-level candidates and PACs have spent $118,005 from their campaign accounts on services from the United States Postal Service in the 2022 election cycle so far. USPS received 0.3 percent of all $34.3 million in reported expenditures.